As ever, the series was marked by several cast changes. This series saw the arrival of Alex Mytton's friend Sam Harney, Ollie Locke's love interest Emma Walsh, Victoria Baker-Harber's friends Tallulah Rufus-Isaacs and Brigita Baniunaite, and James Dunmore's ex-girlfriend and Tiff Watson's friend Lily Ludovici. It also briefly featured Alik Alfus' father Mitch. Of these, only Tallulah returned for series 11, though only Emma has explicitly confirmed her departure.
The series also marked three major returns to the cast (aside from those absent from Made in Chelsea: LA), with Ollie returning full-time following an appearance at the end of LA, alongside his friend Richard Dinan who previously appeared from the third to fifth series. The third returnee was Francis Boulle, who returned briefly for the Christmas special, having last appeared in the sixth series. In a minor role, Tiff and Lucy Watson's father Clive also reappeared in this series.
In terms of cast departures, primary cast member Spencer Matthews made his final appearance in the eighth episode to appear on I'm a Celebrity...Get Me Out of Here! Having debuted in the very first episode, Spencer's departure meant the rest of the tenth series featured only four other original cast members: Alexandra "Binky" Felstead, Rosie Fortescue, Mark-Francis Vandelli and Ollie, alongside Louise Thompson who only recurred in the first series.
Though unconfirmed, it is also possible that the tenth series marked the departures of series stalwart Oliver Proudlock who debuted in series 2, who having decided to take a break from the series only appeared in the ninth episode, and alongside series 9 debuting Emily Weller, has not been announced as returning for series 11. Like Proudlock, Emily only appeared in one episode, the second.
- New cast members' names are highlighted in bold.
- Emma Walsh @missemmawalsh, Twitter, 15 March 2016, accessed 1 April 2016
- Anna Howell, 'Spencer Matthews has QUIT, but is he gone for good?', Unreality TV, 17 November 2015, accessed 15 December 2015
- Author unlisted, 'Oliver Proudlock: “I’m taking a break from MIC”', New!, 23 October 2015, accessed 14 April 2016